We recently received a peripheral blood sample on an 80 year old gentleman with mild leukocytosis and an absolute lymphocytosis (WBC-13,700/ul, 70% lymphocytes). Many of the lymphocytes had the morphology of LGLs. The lymphocytes showed expression of CD8, CD3, CD7, CD11c and CD16 without significant expression of CD4, CD2 or CD5. The phenotype is good for the T-cell type of LGL. Interestingly, the cells also showed relatively bright expression of CD19. I found a couple of case reports describing similar cases with CD20 but not with CD19. Has anyone else seen this in their personal experience or documented in the literature? Thanks in advance for your input. Christopher S. Bee, M.D. Medical Director, Cellular Immunology and Flow Cytometry Wilford Hall Medical Center Lackland AFB, Texas (210) 292-5455 DSN 554-5455 christopher.bee@59mdw.whmc.af.mil
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