A 64year old gentleman with pancytopenia (WBC: 2 K/uL, Hbg:8.0g%, Plt: 80,000), found on a routine blood count. No infections, no splenomegaly, "healthy". He comes from Chernoble and works as a carpenter. Bone marrow aspirates twice were dry taps so a sample of peripheral blood was sent for phenotyping. 20% of his lymphocytes were strongly positive for CD103, CD22, CD19, CD20, Lambda, CD11c and CD10 with only about 30% of the cells showing weak to moderate staining for FMC7 They were negative for CD25 and CD38. TRAP is positive in these cells but morphologically they are not quite classical hairy cells. Can this be a HCL variant? Has anyone seen a lymphoma with monoclonal B cells strongly positive for CD103 and CD11c ? Judy Judith Chezar Head Hematology and Blood Bank laboratories Hospital of Western Galilee Nahariya, Israel
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