Re: hematogones

From: sterling stoudenmire (sstouden@thelinks.com)
Date: Wed Feb 07 2001 - 20:55:47 EST


andrea, some of these markers might be specific to the location from which
the sample was taken?  any comments on that issue? sterling

At 01:12 PM 2/5/01 -0500, Andrea Illingworth wrote:
>   Another question for the flow experts:   of B-cell  differentiation:
>CD45 dim,  very low FALS Pop#2: CD19+, CD10+ (a little weaker than the
>first  pop.), CD34-, weak CD20 and CD22, no k/l, CD45 ( a little brighter
>than pop 1),  very low FALS Pop#3: CD19+, CD20+ (bright), CD22+ (bright),
>polyclonal kappa and lambda, bright CD45+       Which ones are the
>hematogones, only the first population or  is the second population
>(CD10+,CD34-) also called hematogones? What is the  definition of
>hematogones? Are they always CD34+?  1 and 2, they seem to "jump" from
>being CD34+ to  being CD34 negative without the stages in between.   Thank
>you for any insight Andrea Illingworth DCDS Flow Cytometry Bangor, Maine
Computer Aided Cell and Molecular Biology (CACMB), not medicine, will find
the cure for cancer and other diseases.  There will always be a need for
the trained clinician (MD/RN) but, advanced diagnostic and treatment option
selection has become gene based, has moved from the physician's practice to
the computerized cell and molecular biology laboratory, and appropriate
treatment options should now be based on the personal biology of the
patient.



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