Dear WK LEE A CD45 negative ALL is not an unusual finding... among other sources of info, look for an upcoming CPC in the New England J. Med for a review. I would not consider the expression of CD13 alone to have this qualify as a 'biphenotypic' malignancy ...is there any MPO expressed? ..if so, I would start to consider biphenotypy. As already described, your tumor immunophenotype is squarely a B cell process...CD79a+ might help to convince any skeptics. F Preffer At 10:28 AM 8/19/00 +0800, hkleewk@netvigator.com wrote: > >Dear Flowers, >I've come across a leukaemia case of CD45 dim or maybe negative expression. >Have any dear friends got experience on this kind of cases? >We've done the 3-color immunophenotyping, using SS/CD45-PC5 as the gating >stretegy. The gated population on bone marrow specimen has positive >expression of CD19, CD10, HLA-DR, CD13, CD34; negative expression of CD14, >CD3, CD5, CD7 and sIg. Weak expression of CD13 was also observed. We're >waiting for the t-dT result by immunohistochemical detection. Would you >consider these findings are case of biphenotyping leukaemia or ALL with >abberrant expression of myeloid marker?? > >WK LEE > Frederic I. Preffer Department of Pathology Charlestown Navy Yard- 7140 Massachusetts General Hospital East Charlestown, MA 02129 voice [617] 726-7481 fax [617] 724-3164
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