To my knowledge, in non-neoplastic conditions, CD4-/CD8- T cells are almost always gamma/delta cells. Loss of CD4 or CD8 in an alph/beta cells is suggestive of an aberrant phenotype or possibly lymphoma. Increased gamma/delta cells are increased in several inflammatory conditions especially those that are granulomatous. Examples include tuberculosis, MAI, leprosy, and Crohn's disease. I wasn't aware of the ethnic variations. Thank you. Jeff Vos Pathology Resident
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