Bruce, I think it is a very good idea provided that these cases can be put on a specific website for people to look at, alternatively put together in a publication when there are enough cases in the registry. There are obviously cases that are CD5+CD23- that do not fit Mantle diagnosis. Digging out old cases may be difficult but as soon as new one appears I will send the data. Kind regards Anna At 07:52 2000-08-02 -0400, you wrote: > >My experience parallels Dan, but I think we are in uncharted waters here and have an >opportunity to do some good science. I would propose that through this website we >establish a registry of CD5+ lymphoproliferative disorder that are not clear cut CLL or >Mantle Cell. I suggest that anyone with such cases send a message to this listserve >and also to the Clinical Cytometry Society c/o Carol Eckenweiler (copied above). >Relevant information should be case number, institution, age and sex of patient, summary >of phenotypic findings (list mode files would be an even greater contribution), clinical >findings and brief history if available, and salient morphologic findings (image files >would be welcome), but to respect good ethical practice no information allowing ready >identification of individual patients (no names or patient ID information) should be >included. Such a data base could be of value in better understanding the specificity >of analytical cytometry in disease diagnosis and classification. > >Any support to this idea? > >Best regards, > >Bruce > >Bruce H. Davis, M.D. >Maine Medical Center Research Institute >125 John Roberts Rd., Suite #8 >South Portland, Maine 04106 > >207-842-7914 >FAX: 207-761-2130 >Email: davisb@mail.mmc.org > >>>> "Daniel Arber" <darber@coh.org> 07/31/00 03:14PM >>> > >I don't think that CD5+ SLVL is a specific pathologic diagnosis, and is >unlikely to correlate with a tissue diagnosis of splenic marginal zone >lymphoma. > > Dan Arber > City of Hope > > ____________________Reply Separator____________________ > Subject: Re: interesting case > Author: Anja Porwit <Anja.Porwit@ks.se> > Date: 07/31/2000 4:59 AM > > > > > Hello, > CD5 can be positive in some cases of splenic lymphoma with > villous > lymphocytes - could that diagnosis fit the cytology of the > cells in BM? Was > CD11c positive? Tartrate resistant acid phosphatase? > Best wishes > Anna > > At 16:24 2000-07-27 -0400, you wrote: > > > >We have a case of an 80 year old male, with bone marrow biopsy > >showing lymphoproliferative process and enlarged spleen. The > bone > >marrow tumor cells are reported cyclin D1 negative. The case > was > >submitted with a diagnosis of hairy cell. WBC is 2.2 with > anemia and > >thrombocytopenia. The peripheral blood is minimally involved > (7% of > >lymphs). The tumor cells are CD19+, CD20 moderate (not dim), > CD22 > >moderate, Immunoglobulin moderate- kappa/IgA IgM +, CD5 > positive but > >spectrum from dim to moderate, FMC7 + and negative for CD23, > CD10, > >CD103, CD25, CD38, IgD, IgG, and IgE. This doesn't look like > CLL or > >mantle cell. We will be following up on the marrow biopsy and > further > >clinical history and will let you know anything that pops up. > Has > >anyone had a case like this? What is your favorite diagnosis > for this? > > > > > > Maryalice Stetler-Stevenson and Doug Kingma > >Maryalice Stetler-Stevenson > >Director Flow Cytometry Unit > >Laboratory of Pathology, NCI, NIH > > > Anna Porwit > Hematopathology Lab. > Department of Pathology > Karolinska Hospital, Stockholm > Anja.Porwit@ks.se > tel.:+46-851774518 > fax.:+46-851775843 > > > > Anna Porwit Hematopathology Lab. Department of Pathology Karolinska Hospital, Stockholm Anja.Porwit@ks.se tel.:+46-851774518 fax.:+46-851775843
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