Hello, CD5 can be positive in some cases of splenic lymphoma with villous lymphocytes - could that diagnosis fit the cytology of the cells in BM? Was CD11c positive? Tartrate resistant acid phosphatase? Best wishes Anna At 16:24 2000-07-27 -0400, you wrote: > >We have a case of an 80 year old male, with bone marrow biopsy >showing lymphoproliferative process and enlarged spleen. The bone >marrow tumor cells are reported cyclin D1 negative. The case was >submitted with a diagnosis of hairy cell. WBC is 2.2 with anemia and >thrombocytopenia. The peripheral blood is minimally involved (7% of >lymphs). The tumor cells are CD19+, CD20 moderate (not dim), CD22 >moderate, Immunoglobulin moderate- kappa/IgA IgM +, CD5 positive but >spectrum from dim to moderate, FMC7 + and negative for CD23, CD10, >CD103, CD25, CD38, IgD, IgG, and IgE. This doesn't look like CLL or >mantle cell. We will be following up on the marrow biopsy and further >clinical history and will let you know anything that pops up. Has >anyone had a case like this? What is your favorite diagnosis for this? > > > Maryalice Stetler-Stevenson and Doug Kingma >Maryalice Stetler-Stevenson >Director Flow Cytometry Unit >Laboratory of Pathology, NCI, NIH > Anna Porwit Hematopathology Lab. Department of Pathology Karolinska Hospital, Stockholm Anja.Porwit@ks.se tel.:+46-851774518 fax.:+46-851775843
This archive was generated by hypermail 2b29 : Wed Apr 03 2002 - 11:55:58 EST