Hi Paul, It could look OK in that it shows the percentage of cells which are not resting, as long as the slash in "G2/M" is read in the cell-cycle and not the mathematical sense (ie "G2 and or M", not "G2 divided by M"), I'd personally write it thus MPI = (S+G2+M)/(S+G2+M+G0+G1) to remove the ambivalence (but I might have the wrong end of the stick). Ray At 1:19 pm -0400 18/7/00, Paul Harris wrote: >Hi DNA experts, > >A recent article on growth of pterygium on the eye ( Investigative >Ophthalmology and >Visual Science, June 2000, by Donald Tiang-Hwee Tan) uses a mean >proliferation index >to evaluate the proliferative status of conjunctival epithelium >versus conjunctival >fibrovascular tissue. The calculation that is used is new to me and >I was wondering >if other experts in the field have tried this. The test data is from >using Cellfit >software (version 2.0) DNA software. The MPI defined in the paper >is as follows: >MPI= (S+ G2/M) to (S+G2/M+GO+G1). > >Is this a valid index of proliferation? If it is, I would appreciate >any references >you may have. > >Paul Harris, >Flow Cytometry Lab, >Department of Pathology >St Josephs Health Care >London, Ontario > >Paul.Harris@sjhc.london.on.ca
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