Re: APC on FACS Vantage

From: D. Coder (dcoder@u.washington.edu)
Date: Sun Jun 04 2000 - 11:52:31 EST


On Fri, 2 Jun 2000, Len Brown wrote:

>
> Dear All
>
> We are attempting to set up 4 colour assays on our FACS Vantage (NOT SE
> upgraded) using APC on a HeNe laser delivering about 30 mW. Abs are from BD.
>
> 1) Should we expect to see the APC signal in the FL3 channel (optimised for
> PECY5) of our 488 nm line? ie. Is APC excited at all by the 488 nm laser?
>
yes, APC is excited just a bit by 488n,m light. If you want to separate
APC single positive cells or APC dim cells then use PE-TxRed since you
cannot compensate; the reciprocal Cy5  in APC can only be done with the
OmniComp add-on or the new digital system when released.

Dave
> 2) Is anybody using BD's CD11c-APC mAb on a similar system, if so how does
> the signal compare with PE.
>
> Any help or hints on setting up 4 colour on a Vantage with 488 and 635 nm
> laser lines would be most appreciated.
>
> Len Brown
>



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