Re: Cell counting

From: N.W.BLACKHALL (Nigel.Blackhall@nottingham.ac.uk)
Date: Tue Nov 02 1999 - 05:34:38 EST


Dear all

Sneza asked about using a Facs for absolute cell counts/concentration.

You may wish to refer to the following article:
THE QUANTITATION OF THE ABSORPTION OF MICROPARTICLES INTO 
THE INTESTINAL LYMPH OF WISTAR RATS 
AU: JENKINS_PG, HOWARD_KA, BLACKHALL_NW, THOMAS_NW, 
DAVIS_SS, OHAGAN_DT 
JN: INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1994, Vol.102, No.1-
3, pp.261-266 

Using an EPICS V I found that for a narrow dynamic range, i.e. 1-1000, I 
could use an internal standard to calculate the concentration.

For a much broader range, I found it necessary to replace the sample input 
system with a syringe pump at a constant velocity and then just count the 
number of particles per unit time.

Regards
Nigel Blackhall,
Experimental Officer, Plant Science Division,
School of Biological Sciences, University of Nottingham,
University Park, Nottingham NG7 2RD, UK
Tel +44 115 9515151 ext 18501
Fax +44 115 9513298



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