Dear Brian, If adhesiveness of platelets is excluded, nothing argues against M7. For preB-ALL we would expect CD10, 19, DR, 34, cytoplasmic CD79, cyTdT. Clinical information, CBC and ideally jpeg-files from the morphology are helpful for submission of such cases. Thomas Nebe Klinikum Mannheim D-68135 Mannheim > -----Original Message----- > From: Newsom, Brian S. [SMTP:BSNEWSOM@txccc.org] > Sent: Thursday, September 16, 1999 11:42 PM > To: Cytometry Mailing List > Subject: Interesting case > > I have an interesting/puzzling case for the group. A 16 month old Female, > (non-Downs) was diagnosed with M7 seven weeks ago. She was not doing well > on > therapy and we got the case. Her morphology shows large blebbing > blast-like > cells but her cytogenetics look very pre B-ALLish, WBC is 3.2X10^6/mL. Her > flow > is as follows: > > Positive for CD38, CD42a, CD56 and CD117 > > Partially/Dimly positve for CD33 and CD61 > > Negative for CD3, CD4, CD5, CD7, CD8, CD11b, CD13, CD14, CD15, CD16, CD19, > CD20, CD34, CD95, Kappa, Lambda, TdT, MPO and HLA-DR > > There also is a population of about 0.5% of the BM that is CD10+CD22+ (pre > B-ALL fraction of two clones?) which falls in the same CD45vs.SSC gate but > seems negative for all other markers. > > Any ideas? > > Brian Newsom > Director, Flow Cytometry > Center for Cell and Gene Therapy > Baylor College of Medicine << Datei: ATT00411.ATT >>
This archive was generated by hypermail 2b29 : Wed Apr 03 2002 - 11:54:00 EST