Dear Collegues, Dr. Serke from Berlin reported on our IGLD meeting in Magdeburg this year from several cases and we had one case of AILD (angioimmunoblastic lymphoproliferative disease) with CD4+3-. We have not checked CD30 and I think Stefan did not either. The clinical picture you reported is not typical for AILD (lung involvement?). Your panel for NHL typing in peripheral blood sounds strange compared to the established ones. CD4 vs CD7 should be included if you suspect Sezary Syndrome. Morphology is also typical (gyriform nuclei). Anaplastic large cell lymphoma (ALC) gives a typical picture in BM histology as it surrounds the blood vessels. It might be difficult to see in paraffin embedded sections. Metacrylate is superior. We all know about the variations in the NHL types. Clinical data eg. of lymph node status (histology?), blood counts and morphology information etc. are nice if you ask for help. I hope jpeg files from stained smears and list mode data will be available in the future in such cases. Please contact Stefan at: Serke, Stefan MD, PhD Abt. Hämatologie und Onkologie Univ.Klinikum Rudolf Virchow Augustenburger Platz 1 D-13353 Berlin Phone 030-4505-9868, -9888 Fax 030-4505-3914 I think he has no e-mail yet. Regards Thomas Nebe Dr.med. C. Thomas Nebe Universitaetsklinikum Mannheim Zentrallabor Theodor-Kutzer-Ufer 1-3 D-68167 Mannheim Tel. +49 621 383-3485 FAX +49 621 383-3819 e-mail: thomas.nebe@ikc.ma.uni-heidelberg.de http://www.ma.uni-heidelberg.de/inst/ikc/
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