> I sent the first message too soon. The "NK-cell" leukemia is CD5+, CD2+, > CD3-, CD4+, CD8-, CD57+, CD56- and CD16- but we don't know TRCab. The > patient has had some sort of lymphoproliferative process for a long time. > This smells like a CD3- T-cell tumor to me. NK cell neoplasms are usually > CD56+ and aggressive. Any thoughts? Anyone seen this before? > > Maryalice > Maryalice Stetler-Stevenson > Director Flow Cytometry Unit > Laboratory of Pathology, NCI, NIH The expression of CD4 and CD5 would be extremely unusual for an NK cell process, and I agree are most consistent with a T-cell neoplasm. We certainly have seen CD3- T cell lymphoproliferative disorders that have unusual immunophenotypes like you are reporting. Demonstration of clonality by T-cell PCR of either gamma or beta chain would help confirm the T cell nature of the process. -- Brent Wood MD PhD Associate Director of Hematology Laboratory University of Washington Medical Center EM: woodbl@u.washington.edu Phone: (206) 548-6199 Fax: (206) 548-6189
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