Can any of you tell me of a source other than Alfacell Corporation
for the 12 kDa protein homologous to pancreatic RNase A that is isolated
from amphibian oocytes and is known by several names, including P-30
Protein, Pannon and Onconase?
I would like to use this protein in my research because it can block
cell cycle progression at a point that is well-defined. That is, it
halts progression at the Cdk4/6 restriction point by causing reduced
cyclin D and increased Cdk inhibitor expression.
Alfacell Corporation is currently using what they call onconase in
Phase III clinical trials for cancer therapy. Getting a compound that is
being tested in IND research would require more steps than just
purchasing from an alternative source, so I am asking if anyone out
there knows of one.
Dr. Kevin G. Waddick
Hughes Institute
2657 Patton Road
St. Paul, MN 55113
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