sorting bacteria for DNA content

From: Arne Rietsch (arietsch@mbcrr.harvard.edu)
Date: Mon May 03 1999 - 09:28:22 EST


Hi!

I'd like to use FACS to analyze the DNA content of bacterial cells in a
population (the question is if the bacterium we're studying segregates
daughter cells carrying only one of the chromosomes under starvation
conditions. These cells should be detectable as a population with
dramatically reduced DNA content.)
I was wondering if there are protocolls out there for staining bacteria
for FACS analysis. Preferably a stain that does not overlap with the
emisssion spectrum of GFP. Also the FACS that is available to me does not
have a UV laser, i.e. DAPI will not work.
I'd appreciate any info/protocols you may have to offer!

Thanks!

Arne

____________________________________________
Arne Rietsch
Dept. of Microbiology and Molecular Genetics
Harvard Medical School
200 Longwood Ave., Boston, MA 02115
Phone:(617) 432-0832
FAX:  (617) 738-7664



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