Hi, M7 are very rare and I have seen only a couple, they were also TdT negative. what I wrote about checking CD61 and cyt.B markers is our general policy in leukemia diagnosis and as I indicated both B origin and M7 were unlikely! As I have seen on the mailing list most people agree with very early AML. Best wishes Anna At 11.34 1998-01-21 -0200, you wrote: > > > Dear Dr. Anna, > > I became curious about your answer. I agree with the AML >M0 hypotesis, but have you seen M7 positive for TdT? In the very few cases >we have seen here so far thay were all TdT negatives. > >Jorge Neumann >Santa Casa Hospital >Porto Alegre, Brasil > >On Tue, 20 Jan 1998, Anna Porwit-MacDonald wrote: > >> >> >> Hi, >> The immunophenotype you gave is consistent with AMLM0, but I would do the >> cyt.CD79a and CD61 just to exclude (unlikely) early-B-precursor and M7. >> Best wishes >> Anna >> >> Anna Porwit-MacDonald >> Haematopathology Lab. >> Karolinska Hospital, Stockholm >> >> At 12.11 1998-01-19 -0500, you wrote: >> > >> >We are discussing a case of acute leukemia with the following results: >> >Morphology - 93% undifferentiated blasts. >> >CD 45 POS(DIM), CD7 POS, HLA-DR POS, CD34 POS, CD13POS (DIM), >> >TdT POS. >> >Negative for MPO,CD2, CD3 (surface and cytoplasmic), CD4,CD8, CD19, >> >CD20, CD10, CD14,CD33. >> >Debate-Undifferentiated or MO? (or something else!!?) >> >Comments please! >> > >> >Mike Keeney >> >London Health Science Centre >> >Canada >> > >> > >> Anna Porwit-MacDonald >> Heamatopathology Lab. >> Department of Pathology >> Karolinska Hospital, Stockholm >> anpo@mb.ks.se >> tel.:+46-851775863 >> fax.:+46-851775843 >> > > > Anna Porwit-MacDonald Heamatopathology Lab. Department of Pathology Karolinska Hospital, Stockholm anpo@mb.ks.se tel.:+46-851775863 fax.:+46-851775843
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