T-cells coexpressing both CD4 and CD8 have been reported in blood/tissue
from patients with a variety of disorders including lymphoproliferative
diseases, autoimmune disorders as well as in healthy individuals. With
respect to the latter, investigations utilizing animals suggest that the
dual expressive cells are associated with intestinal epithelial lymphocytes;
furthermore it appears that the presence of these cells is assoicated with
age and microbial infection. Other invertigators have demonstrated that
dual positive T-cells can be induced in vitro. I call your attention to the
following references:
cell immunol 164:36, 1995
Br. J. Haematol 82:494, 1992
Blood 82:1546, 1993
Cancer 67, 2610, 1991
Am J Pathol 134, 761, 1989
Clin Exp Immunol 45, 1 1981
J Clin Immunol 13, 113, 1993
J. Neuroimmunol 11, 311, 1985
Scand. J. Haematol 30, 401, 1983
Nature 322, 462, 1986
J. Immunol 151, 6681, 1993
Eur J Immunol 22, 159, 1992
BBRC, 191, 601, 1993
Scand J Immunol 35, 439, 1992
J Immunol 134, 2281,1985
Nature, 335, 642, 1988
Bruce Shenker
Dept. of Pathology
School of Dental Medicine
University of Pennsylvania
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_/_/_/_/ _/_/_/_/ _/ _/ _/ _/ Bruce J. Shenker Ph.D.
_/ _/ _/ _/_/ _/ _/_/ _/ shenker@path.dental.upenn.edu
_/_/_/_/ _/_/_/ _/ _/ _/ _/ _/ _/ (215)898 5959;FAX 573 2050
_/ _/ _/ _/_/ _/ _/_/ School Of Dental Medicine
_/ _/_/_/_/ _/ _/ _/ _/ THE UNIVERSITY OF PENNSYLVANIA
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