Ken, I have certainly seen expression of antigens in malignancies vary upon site of aspiration. We had a case which, like yours, had two populations morphologically which had a phenotype of CD 5/19/20/22/23/Lambda+++/FMC7neg on all cells of which over 50% also showed distinct CD6 and CD11a positivity. That was in the peripheral sample whereas the bone marrow showed only a few of the CD6/11a positives. Similarily, a couple of CD2 positive "common" ALL's showed distinct CD2 pos and CD2 neg subsets which differed considerably in percentage between periphery and bone marrow. Wal Sharp
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