qualitative bacterial agglutination by flow

From: Hughes, EJ, Jane, Ms (JHUGHES@ich.uct.ac.za)
Date: Mon Nov 24 1997 - 16:08:57 EST


Hi all Flowers

Our laboratory has been trying to perform a qualitative agglutination
assay for Bordetella Pertussis in pre and post vaccinated sera using 
a visual end point. The results are not satisfactorily reproducible 
from one reader to another. The end point is very subtle; a fine 
microagglutination that is recommended to be read under oblique 
light with a magnifying glass.

Have any of you any experience with bacterial agglutination by flow. 
We have a Coulter XL; I have no prior experience with 'bugs' and 
would need some guidance as to recommended settings etc. 

I am VERY keen to eliminate the human error apparently inherent in 
this assay...am I asking the impossible!!!??
Jane Hughes
Chief, Institute of Child Health Lab,
Red Cross Children's Hospital
Rondebosch, Cape Town 7700.
South Africa

Tel 021 658 5315
Fax 021 689 1287



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