Kappa/lambda on hairy cells

From: STEPHEN J COUZENS (CouzensSJ@cardiff.ac.uk)
Date: Tue Nov 18 1997 - 08:43:28 EST


Hello everybody,

We use a kappa/lambda/CD19 triple to establish clonality for B cells, 
but  we are noticing that some of our cases of Hairy cell leukaemia 
appear "double stained" for kappa and lambda. We use 2% bovine serum 
albumin in our wash buffer and have tried blocking with various 
reagents, but no luck so far. Has anyone come across this problem, or 
have any ideas? 

Thanks in advance

Steve Couzens
(Couzens@cf.ac.uk)



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