cross-reactive MoAbs

From: Mara Rocchi (M.ROCCHI@CGNET.COM)
Date: Thu Sep 25 1997 - 12:47:00 EST


For Keith Bahjat, trough the cytometry list because my postmaster doesn't 
like his address.
That's for the species cross-reactivity chart:

Dako Rabbit anti-human T cell, CD3, code n.  A 452
cross react with bovine cells

This antibody recognize the intracytoplasmic portion of human CD3, and is 
recommended for histopathology. I tested the antibody in flow cytometry on 
bovine PBMC, by intracytoplasmic stain and it works very well. Double 
staining (surface + cytoplasm) with anti-bovine CD3 showed positivity  in 
CD3 surface positive cells only. IgM positive cells (surface) were negative 
for cytoplasmic CD3.

Hope this help. Cheers, and thanks for the work you're doing. Sometimes is 
not easy for us (people that don't work with human, mouse o rat) to find the 
antibody you're dreaming for.

Mara


Mara Rocchi, DVM Ph.D.,
Lab 4,
International Livestock Research Institute
P.O. box 30709
Nairobi, Kenya
Fax: 00254-2-631499
Mail: M.Rocchi@cgnet.com



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