Peter, A detailed description of antigenic changes in B-lymphoid development can be found in the following reference: Loken, et al. Flow cytometric analysis of human bone marrow: II. Normal B lymphoid development. Blood 70: 1316, 1987. The normal stages of development can only be observed in a multicolor analysis. In patients post therapy, early B cells (hematogones) can be observed and must be differentiated from ALL using multiparameter/multidimensional analysis. Also see the CD-ROM current protocols on how to do this. Denise Wells
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