FITC detection limit for a normal fluorescent microscope, NOT A CONFOCAL

From: Bob Ashcroft (cytomat@netcore.com.au)
Date: Wed Aug 20 1997 - 20:01:38 EST


My fresh batch of Quantum 24 beads have 6,000, 16,000, 37,000 and 90,000 
MESF molecules respectively in the particle mixture. The fluorochrome is 
FITC.

When I look at them on the fluorescent microscope, I can only see the ones 
with 90,000 MESF.

Is this normal?

....If not, what is the limit for a dark-accomodated eye?
Yeah, allow for normal biological variation, by assuming I have 20+/20+ 
vision!

....If not, what do I do about it?

(I know fading is a problem, and have had useful suggestions on this 
previously.
We want to use a high sensitivity, 5 mLux, camera to quantify fluorescence)

Thanks,
Bob



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