A question to the those on the list with experience in early B cells in normal bone marrow:- Would you expect SURFACE CD22 to appear before CD20 in normal B cell development ? The reason I ask is we had a BM specimen in the other day in which we found a population of CD19+/10+/20+/22neg/45dim cells which is a phenotype we have seen on some of our NHL's with marrow involvement (& of course 22 is neg on most of our CLL's). I ran out of specimen before I could do any more CD's. The percentage of these cells is too low to give a definitive diagnosis and I don't want to mix up lymphoma cells with normal precursors. Sorry for such a basic question but I deal almost exclusively with ALL's where CD22 almost invariably appears before CD20 on the surface - at least with our leuks, which tend to be different from "western" types We have asked them (another hospital) to send us a suspension from a node biopsy. Thanks Wal Sharp SQU Oman (for the time being!)
This archive was generated by hypermail 2b29 : Wed Apr 03 2002 - 11:50:00 EST