RE: Sorting Question --- look Ma, no satellites!!!

From: Bob Ashcroft (cytomat@netcore.com.au)
Date: Sun Jun 22 1997 - 23:33:23 EST


Dear Vince and Colleagues,

I have found it possible to eliminate those satellite droplets; the finding 
was quite by chance.

The earlier version of the drop drive hardware was recently upgraded on the 
MoFlo, and this extended the available drop drive amplitude from 10 volt to 
virtual infinity (it can go over 110 v, but I stopped there). I describe 
what happens in the 1 to 30volts range.

As the drive amplitude is increased from zero, the strobed image shows 
satellite drops of 1/50th diameter, alternating with the standard large 
drops. Increasing the drive amplitude further, leads to satellites which 
are re-absorbed into preceding or following droplets. As the amplitude is 
increased further, the interval required before reabsorption occurs 
decreases with rising amplitude of drive voltage. Next there is a stage 
where the satellites show as bulges (Ray Hicks' nipples?) on the forming 
break-off drop, but don't actually separate. Further amplitude increases 
result in clean droplets, with no suggestion of satellite production. This 
is where I set the drive value.

For most other sorters, my recommendation is to drive the stream at near 
maximum voltage (short of causing too harsh a distortion envelope), to 
minimise satellite production at least. It also helps if the delay is 
minimal. There are sound arguments which support the idea that highest 
stability occurs at the "point" of shortest delay.

Best regards, Bob

Vincent Falco requests help:
>
>
> My problem is this:During some sorts I get ,what I will call a spurious 
extra
> drop. To explain more,there are times I sort to polycarb filters.When all 
is
> well I get a single spot which contains the desired cell population.When 
all
> is supposed not well I get my desired single spot with cells and just 
about a
> quarter of inch from the desired spot I observe a spurious spot,which 
does
> not contain the desired cells.



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