Assuming that you are interested in detecting autoantibodies or alloantibodies to platelets, I would suggest looking at the following paper. I have not tried this method, but it appears to be far more specific than any other method for identifying specific epitopes and eliminating non-specific binding. Koksch M, Rothe G, Kiefel V and Schmitz G. Fluorescence resonance energy transfer as a new method for the epitope-specific characterization of anti-platelet antibodies. J of Immunological Methods 187: 53-67, 1995. Good luck, Tony Bakke
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