From: Witzig, Thomas E., M.D. Subject: RE: Hepatic Splentic gamma-Delta T-cell Lymphoma I have had some experience with this entity and we are writing up the Mayo cases seen so far. Unfortunately, its an aggressive disease. There are no known protocols - its really too rare for a protocol. I'd recommend: 1. An adriamycin containing regimen such as CHOP, CDE infusional (actually ECOG does have this open as a protocol and the patient could probably enter it --its for aggressive NHL not specifically gamma-delta), ProMACECytaBOM 2. If responsive, I'd check the blood and marrow and transplant if clean. 3. If not a transplant candidate and does not get a CR with regimen in #1 then I'd try a platinum regimen OR 2-deoxycoformycin- Pentostatin (good for T-cell processes and commercially available and usually outpatient and well-tolerated. Sincerely, Tom Witzig (witzig.thomas@mayo.edu)
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