Calman, There are only three antibodies in the world capable of exerting a culpable block to antigen presentation; that principally because they have been shown to specifically bind across the binding site for peptide. The first and perhaps most well known is the famed YAe antibody specific for I-A of b in the presence of a peptide derived from I-E. This came from the work of Donal Murphy, now at the Wadsworth Center in Albany, New York and Charles Janeway at Yale. The second is an antibody to I-A of s from a group in Israel and the third is an antibody to human class II created in the laboratory of Thomas Braciale at the University of Virginia. Gene Pizzo ---------- From: Calman Prussin To: cyto-inbox Subject: anti-HLA mAb Date: Wednesday, April 02, 1997 8:24PM I am looking for an antibody against human MHC II for use in tissue culture to block antigen presentation. Ideally it would recognize a monomorphic determinant on DP, DQ and DR and be sold without azide. Any ideas? I have yet to have much luck after calling a half dozen companies and another half dozen friends. Thanks, Calman _______________________ Calman Prussin Laboratory of Allergic Diseases NIAID/ National Institutes of Health 10 Center Dr., MSC-1881 Bethesda, MD 20892-1881 (301) 496-1306 (Voice) (301) 480-8384 (Fax) calman@nih.gov
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