Hi everyone, We recently processed a hepatosplenic lymphoma in an 18 y/o BM which was very aggressive and which had the following phenotype: CD2+, CD3+, CD5-, CD7+, gamma/delta-TCR+, alpha/beta-TcR+, CD4-, CD8ñ, CD56+, and CD11c+. It showed J-Beta rearrangement bands, and this resembles the rare, but previously reported cases of aggressive gamma-delta T cell lymphomas. Checking several times, we confirmed the coexistence of the two forms of T cell receptor (a/b, g/d) on the cell surface. I have never seen any T cell tumor that coexpressed two TCR forms and I would appreciate any comments or advice from those of you who may have had previous experience with a similar tumor. Thanks, Phil Ruiz U. of Miami
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