Re: murine stem cells

From: STEVEN DAVID GORE (sdgore@welchlink.welch.jhu.edu)
Date: Thu Jan 16 1997 - 11:45:14 EST


On Wed, 15 Jan 1997, Arnold Mixon wrote:

> 
>    An investigator read somewhere(?) of a panel of monoclonal Abs used
> to identify murine progenitor/stem cells.  Of interest is an antibody called
> "lin-neg."  Anyone out there heard of it before/know of it's source? It
> sounds like it might be a cocktail of different Abs.
> Thanks,in advanced, to all responses. 
> 

Lin neg refers to a variety of antibody cocktails or sequential antibody 
screens to assure that a putative "stem cell" does not express any 
surface antigen felt to denote lineage committment eg CD33, CD19, CD3.

Steve Gore
Johns Hopkins Oncology Center



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