Dear Brent: I have read some of the responses to your question. I certainly agree with Maryalice and Dan from City of Hope. We have flowed many follicular lymphomas (lymph nodes) and their corresponding PB and/or BM samples. By no means are they all CD10 positive. This is based on routine histology as a gold standard, but includes many cases with classic t(14;18) by cytogenetics ie; good cases. I would not make this specific diagnosis on the phenotype you described, as it could fit with several different small cell B-lineage LPDs. Most of the comments Maryalice made are very true. The compilation of all the data may allow a diagnosis in your case, but I would not recommend a specific morphologic call based on a non-specific immunophenotype. Interestingly, even the cases of FL without a t(14;18) by cytogenetics (non t(14;18) FL cases) are CD10 positive at the same frequency as " garden-variety " FL. Randy Gascoyne Hematopathologist
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