Trauma and Thermal Injury
Scientists within the facility are attempting to design a cell
culture model that will replicate the symptoms of endotoxic shock
resulting from trauma such as surgery, thermal injury, or severe
accidents. Certain highly responsive immune cells are grown in
culture and then subjected to the same biochemical stress as in a
human trauma. If this program can demonstrate the importance of
this modality, it may be most useful in assisting us to determine
the most appropriate methods for treatment of shock. We are
currently working with cultures of pulmonary artery endothelial
cells which can be manipulated to identify some of the mechanisms
important for oxidative tissue damage in trauma.
