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Product Information CD56
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Antigen distribution:
CD56, or neural cell adhesion molecule (NCAM) is a sialoglycoprotein mediating intercellular adhesion by homophilic binding to NCAM or to another molecule. The CD56 antigen (NCAM) consists of four major isoforms generated by differential splicing of the RNA transcript. The CD56 antigen is expressed on neurons, astrocytes, Schwann cells, NK cells and a subset of activated T lymphocytes.
Application:
Clone 123C3 monoclonal antibodies recognize two isoforms of the protein, 145 and 185 kD. It is applied in the histological typing of human lung tumors.
It is reactive in frozen sections, paraffin sections and Western blotting. This monoclonal antibody may also be used in ELISA techniques.
Specifications:
Clone 123C3 produces mouse IgG1 immunoglobulins directed against a 145 and 185 kD NCAM molecule.
Typical working dilution in immunohistochemistry is 1:40
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paraffin sections |
flow cytometry |
ELISA |
Western Blotting |
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References:
1 Schol et al. 1988. Int. J. Cancer Suppl. 2. 35-40
2 Moolenaar et al. 1990. Cancer Res. 50. 1102-1106
3 Mooi et al. 1988. Mol and Cel Probes. 2. 31-37.
For research only. Not for use in humans. For in vitro use only.
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