Map 4-Antibodies

FLT3

Clone & Isotype Conjugate Size Format Part Number
SF1.340 Purified 0.2 mg Freeze-dried (in dev’t) IM2036
IgG1 (mouse)

FLT3/FLK2 belongs to the Receptor Tyrosine Kinase (RTK) family of transmembrane glycoproteins which directly binds extracellular ligands and transduces regulatory signals through intracytoplasmic tyrosine kinase activity. Other members of the RTK family are c-kit (CD117), Macrophage Colony-Stimulating Factor Receptor (M-CSFR), and Platelet-Derived Growth Factor Receptor (PDGFR). On normal bone marrow cells, expression of FLT3/FLK2 can be found on fractions of CD34+ as well as CD34- cells. Most of the CD34+++ FLT3/FLK2+ cells co-express c-kit (CD117) at high levels. The SF1.340 antibody is specific for an extracellular domain of FLT3/FLK2. This antibody does not compete with the FLT3 ligand for binding to FLT3.
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