CD58
LFA-3
| Clone & Isotype | Conjugate | Size | Format | Line | | Part Number |
|
| AICD58 | Purified | 0.2 mg | Freeze-dried | | | IM0861 |
| IgG2a (mouse) | FITC | 100 tests | Liquid | IOTest | | IM1218 |
| PE | 100 tests | Liquid | IOTest | | IM1430 |
|
| |
The CD58 antigen is a heavily glycosylated protein of 65-70 kDa, known as the Leukocyte Function Associatedmolecule-3 (LFA-3). It is a member of the immunoglobulin superfamily with two extracellular domains. It is structurally similar to its ligand, CD2, and also to CD48. It mediates the interaction of target cells with activated T cells and thymocytes. When bound to its ligand CD2, it enhances T cell stimulation. This antigen is widely expressed on leukocytes, erythrocytes and endothelial cells. AICD58 antibody is a blocking antibody in LFA-3 mediated adhesion. It was evaluated during the Fifth International Workshop on Human Leukocyte Differentiation Antigens.
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