TCR-Zeta
Clone & Isotype Conjugate Size Format Line Part Number
TIA-2 Purified 100 tests Freeze-dried COULTER CLONE 6604592 IgG1 (mouse)
The z subunit is a 16 kDa surface molecule associated with the T cell receptor. Its expression is restricted to T lymphocytes and natural killer (NK) cells. In T lymphocytes, the z subunit is expressed as a disulfide-linked homodimer of 32 kDa or as a disulfide-linked heterodimer with a 21 kDa subunit designated h. Both of these dimeric species are non-covalently associated with the remaining subunits of the CD3-TCR-antigen receptor complex. In NK cells, the z subunit is expressed as a disulfide-linked homodimer of 32 kDa or as a disulfide-linked heterodimer with a 12 kDa subunit. It is associated with the CD16 molecule (FcgRIII). TIA-2 antibody recognizes a cytoplasmic epitope of the z subunit of the T lymphocyte receptor complex. It is suitable for immunoprecipitation, immunoblotting, and flow cytometric analysis of permeabilized cells. TIA-2 antibody was evaluated during the Fifth International Workshop on Human Leukocyte Differentiation Antigens.
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