Map 4-Antibodies

CTLA-4

Clone & Isotype Conjugate Size Format Part Number
BNI3 Purified 0.2 mg Freeze-dried (in dev’t) IM2070
IgG2a (mouse)

CTLA-4 is an integral membrane protein belonging to the immunoglobulin superfamily, which is expressed either as a 30 kDa monomer or as a disulfide-linked homodimer. It is homologous to the T cell antigen CD28, and like CD28, is a ligand for CD80 and CD86. CTLA-4 is transiently expressed by activated T cells, and is not detectable in resting T cells. BNI-3 is useful for the detection of CTLA-4 by flow cytometry, and can also be used in immunohistochemistry on frozen sections. CTLA-4 and CD28 are involved in the costimulation required for T cell activation.
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