CD117

c-kit — Progenitor cells

Clone & Isotype	Conjugate	Size	Format	Line		Part Number
95C3	Purified	100 tests	Liquid	IOTest		IM1359
IgG1 (mouse)	PE	100 tests	Liquid	IOTest		IM1360
	PE-Cy5	100 tests	Liquid	IOTest		IM2043
17F11	Purified	100 tests	Liquid	IOTest		IM1227
IgM (mouse)	Biotin	0.2 mg	Freeze-dried			IM1228

The CD117 antigen is the protooncogene c-kit which belongs to the class III receptor tyrosine kinase family. This antigen is the receptor for a growth factor encoded by the steel locus (Steel Locus Factor "SLF"). The CD117 antigen is expressed on very few normal bone marrow cells. The majority of CD117+ marrow cells co-express CD34. 95C3 and 17F11 antibodies react with BFU-E, CFU-GEMM, CFU-GM and CFU-G. 95C3 antibody reduces the binding of SLF to its receptor to about half of the maximum value. 17F11 antibody down regulates c-kit in a similar fashion to SLF. 95C3 and 17F11 antibodies were evaluated during the Fifth International Workshop on Human Leukocyte Differentiation Antigens.

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