CDw116

GM-CSF RECEPTOR (a CHAIN)

Clone & Isotype	Conjugate	Size	Format	Line		Part Number
SCO6	Purified	0.2 mg	Freeze-dried			IM1765
IgG1 (mouse)	PE	100 tests	Liquid	IOTest		IM1977
SCO4	Purified	0.2 mg	Freeze-dried			IM1764
IgG1 (mouse)

The CDw116 antigen, a 75-85 kDa molecule, is the human Granulocyte-Monocyte Colony-Stimulating Factor (GM-CSF) receptor a chain. It is not expressed by lymphocytes but strongly by monocytes and granulocytes and their precursors. It is also present on endothelial cells, fibroblasts and Langerhans cells. SCO4 and SCO6 antibodies recognize two different epitopes of the GM-CSF receptor a chain. They are both high affinity antibodies which bind to the membrane and to the soluble form of GM-CSFR. They immunoprecipitate the molecule. SCO4 antibody works in Western blot but SCO6 antibody does not. SCO4 is a blocking antibody because it inhibits GM-CSF-driven cell proliferation of TF1, a human GM-CSF-dependent cell line.

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