CD95

FAS

Clone & Isotype	Conjugate	Size	Format	Line		Part Number
7C11	RD1	0.5 mL	Liquid	COULTER		6607003
IgM (mouse)
* CH11	Purified	500 µg/mL	Liquid (100 µL)			IM1504
IgM (mouse)
* UB2	Purified	100 µg	Freeze-dried			IM1505
IgG1 (mouse)	FITC	50 tests	Liquid (1mL)			IM1506
	PE	50 tests	Liquid (1mL)			IM1739
ZB4	Purified	100 µg	Freeze-dried			IM1737
IgG1 (mouse)

The CD95 (Fas or APO-1) antigen is a 40-50 kDa transmembrane glycoprotein. It belongs to the Nerve Growth Factor Receptor/ Tumor Necrosis Factor (NGFR/TNF) superfamily and contains three cysteine-rich repeats. This cell surface molecule mediates apoptosis (programmed cell death). CD95 antigen is expressed on a substantial proportion of peripheral CD4+ cells, CD8+ cells and B cells but on a minor proportion of Natural Killer (NK) cells. It is not found on platelets or erythrocytes, but is expressed variably on granulocytes and monocytes. CD95 is strongly up-regulated on activated T cells, B cells, NK cells and thymocytes. Moreover it is widely expressed on cell lines of T, B, NK and myeloid lineage. CH-11 antibody induces apoptosis of some CD95 expressing cell lines, in vitro. ZB4 antibody inhibits apoptosis induced by CH-11 antibody. CH-11 and 7C11 antibodies were evaluated during the Fifth International Workshop on Human Leukocyte Differentiation Antigens.

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