CD83

Clone & Isotype	Conjugate	Size	Format			Part Number
HB15a	Purified	0.2 mg	Freeze-dried		(in dev’t)	IM2069
IgG2b (mouse)

CD83 or HB15 is a 45 kDa glycoprotein, member of the Immunoglobulins superfamily. It is composed of a single extracellular V-type Ig-like domain, a transmembrane region and a 40 amino acid cytoplasmic domain. CD83 is predominantly expresssed by dendritic lineage cells including skin, Langerhan's cells and interdigitating reticulum cells present in the T cell zones of lymphoid organs and weakly expressed by some germinal center lymphocytes. HB15 is not expressed by resting blood leucocytes at detectable levels and is only expressed at low levels following lymphocyte activation in vitro. HB15a antibody was evaluated during the Fifth International Workshop on Human Leukocyte Differentiation Antigens.

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