CD69

EARLY ACTIVATION ANTIGEN (EA-1)

Clone & Isotype	Conjugate	Size	Format	Line		Part Number
TP1.55.3	Purified	0.2 mg	Freeze-dried			IM0780
IgG2b (mouse)	PE	100 tests	Liquid	IOTest		IM1943
	PE-Cy5	100 tests	Liquid	IOTest		IM2079

The CD69 antigen is a 60 kDa disulfide-linked dimeric structure, known as Activation Inducer Molecule (AIM). This structure contains two differentially glycosylated forms (33 and 27 kDa) of a single core protein. This activation antigen is the earliest appearing cell surface glycoprotein (before other activation antigens such as IL2-R) after T or B cell activation but is absent in resting lymphocytes. It is also expressed by activated macrophages, by Natural Killer (NK) cells and by other cell types including neutrophils, eosinophils and platelets . Its expression in vitro can be induced by different factors such as PMA, PHA or CD3 monoclonal antibodies. CD69 antibody is useful in combination with CD4, CD8 and CD3 antibodies for T cell activation studies. TP1.55.3 antibody immunoprecipitates the 60 kDa homodimer and both 27 kDa and 33 kDa subunits from activated peripheral blood lymphocytes under reduced and non-reduced conditions. This antibody was evaluated during the Fourth International Workshop on Human Leukocyte Differentiation Antigens.

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