CD63

Activated platelets (GP53)

Clone & Isotype	Conjugate	Size	Format	Line		Part Number
CLBGran/12	Purified	100 tests	Liquid	IOTest		IM0768
IgG1 (mouse)	FITC	100 tests	Liquid	IOTest		IM1165
	PE	100 tests	Liquid	IOTest		IM1914

The CD63 antigen is a lysosomal membrane glycoprotein of 53 kDa that is translocated to the plasma membrane after platelet activation. It is also found on monocytes/macrophages and is weakly expressed by resting granulocytes, T cells and B cells. CD63 antigen, present only in azurophilic granules of non-stimulated neutrophils, is strongly expressed on the surface of neutrophils after activation. CD63 is a marker for granule release. This phenomenom is also reported for basophils. CD63 antibodies inhibit adhesion of neutrophils to activated endothelium. CLBGran/12 antibody was evaluated during the Fourth International Workshop on Human Leukocyte Differentiation Antigens.

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