CD49b

VLA-a2 CHAIN

Clone & Isotype	Conjugate	Size	Format	Line		Part Number
Gi9	Purified	0.2 mg	Freeze-dried			IM0717
IgG1 (mouse)	FITC	100 tests	Liquid	IOTest		IM1425

The CD49b antigen (GPIa) is the 170 kDa integrin a2 chain which is non-covalently associated with the 130 kDa integrin b1-chain (CD29 molecule) forming the VLA-2 complex (GPIa/IIa). It is known as the collagen receptor. It is expressed by platelets, activated T cells and thymocytes. Gi9 antibody reacts with the molecule carrying the Br(a) as well as the Br(b) alloantigen. This antibody inhibits the adhesion of platelets to collagen. CD49b detects human alloantibodies (anti-Br a,b) against VLA-2 by MAIPA assay. It is not suitable for Western blot analysis. Gi9 antibody was evaluated during the Fourth International Workshop on Human Leukocyte Differentiation Antigens.

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