CD41

PLATELET gpIIb

Clone & Isotype	Conjugate	Size	Format	Line		Part Number
69 (Plt-1)	Purified	100 tests	Freeze-dried	COULTER CLONE		6602880
IgM (mouse)	FITC	100 tests	Freeze-dried	COULTER CLONE		6602993
P2	Purified	0.2 mg	Freeze-dried			IM0145
IgG1 (mouse)	Biotin	0.2 mg	Freeze-dried			IM0718
	FITC	100 tests	Liquid	IOTest		IM0649
	PE	100 tests	Liquid	IOTest		IM1416
SZ22	Purified	0.2 mg	Freeze-dried			IM0539
IgG1 (mouse)	Biotin	0.2 mg	Freeze-dried			IM0720
	FITC	100 tests	Liquid	IOTest		IM1756

The CD41 antigen is the integrin aIIb chain, also called platelet gpIIb, which is non-covalently associated with the integrin b3 chain also called gpIIIa (CD61). Together CD41 and CD61 form the gpIIbIIIa complex. This complex is known as the fibrinogen, fibronectin, vWF, vitronectin and thrombospondin receptor. It is expressed by platelets and megakaryocytes and is involved in platelet aggregation. The gpIIbIIIa is absent or strongly reduced in Glanzmann's thrombasthenia. The P2 antibody reacts with gpIIb in the intact complex with gpIIIa. This antibody blocks binding to fibrinogen and inhibits platelet aggregation induced by thrombin, collagen and ADP. SZ22 antibody reacts with gpIIb independently of the presence of gpIIIa. It is found on platelets and megakaryocytes. This monoclonal does not inhibit platelet aggregation and secretion induced by collagen, arachidonic acid, and thrombin. It does not inhibit fibrinogen binding to human platelets induced by ADP, arachidonic acid and PAF. These three antibodies were evaluated during the Fifth International Workshop on Human Leukocyte Differentiation Antigens.

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