CD19
PAN B CELL
| Clone & Isotype | Conjugate | Size | Format | Line | | Part Number |
|
| 89B (B4) | Purified | 100 tests | Freeze-dried | COULTER CLONE | IVD | 6602683 |
| IgG1 (mouse) | Biotin | 100 tests | Freeze-dried | COULTER CLONE | | 6604102 |
| FITC | 100 tests | Freeze-dried | COULTER CLONE | IVD | 6603012 |
| RD1 | 100 tests | Liquid | COULTER CLONE | IVD | 6603024 |
|
| HD237 (B4 Lytic) | Purified | 100 tests | Freeze-dried | COULTER CLONE | | 6603708 |
| IgG2b (mouse) |
|
| * J4.119 | Purified | 0.2 mg | Freeze-dried | | | IM1313 |
| IgG1 (mouse) | Purified | 100 tests | Liquid | IOTest | | IM1283 |
| FITC | 100 tests | Liquid | IOTest | | IM1284 |
| PE | 100 tests | Liquid | IOTest | | IM1285 |
| PE-Cy5 | 100 tests | Liquid | IOTest | | IM1500 |
|
| CYTO-STATS |
The CD19 antigen is a type I integral membrane glycoprotein with a molecular weight of 95 kDa. This molecule is expressed on all normal B cells including pro-B cells, but it is lost in maturation to plasma cells. It is also found on the surface of follicular dendritic cells, on the early cells of myelomonocytic lineage and on most stabilized B cell lines. It is not present on normalT cells, Natural Killer (NK) cells, monocytes, and granulocytes. In vitro studies show that the CD19 antibodies have an inhibitory effect on the activation and proliferation of B cells. They also inhibit the B cell response after co-stimulation by anti-immunoglobulin and interleukin 4. B4 antibody was evaluated during the Second International Workshop on Human Leukocyte Differentiation Antigens. B4 (Lytic) antibody was evaluated during the Third Workshop. J4.119 antibody was evaluated during the Fourth Workshop.
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