CD18

Integrin b2-chain

Clone & Isotype	Conjugate	Size	Format	Line		Part Number
7E4	Purified	0.2 mg	Freeze-dried			IM1567
IgG1 (mouse)	FITC	100 tests	Liquid	IOTest		IM1568
	PE	100 tests	liquid	IOTest		IM1570

The CD18 antigen is the 95 kDa integrin b2-chain which forms non-covalently-bound heterodimers with the integrin a subunits: CD11a, CD11b and CD11c (aL, aM and aX). It is strongly expressed by all human leukocytes. It is known as the receptor for InterCellular Adhesion Molecules (ICAM): ICAM-1, ICAM-2 and ICAM-3 and functions in cell to cell and cell to extracellular matrix adhesion. 7E4 is a blocking antibody in cell adhesion assays.

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