CD13

PAN MYELOID CELLS

Clone & Isotype	Conjugate	Size	Format	Line		Part Number
366 (MY7)	Purified	100 tests	Freeze-dried	COULTER CLONE		6602626
IgG1 (mouse)	RD1	100 tests	Liquid	COULTER CLONE		6602989
SJ1D1	Purified	0.2 mg	Freeze-dried			IM0713
IgG1 (mouse)	Purified	100 tests	Liquid	IOTest		IM0714
	FITC	100 tests	Liquid	IOTest		IM0778
	PE	100 tests	Liquid	IOTest		IM1427
Immu103.44	PE-Cy5	100 tests	Liquid	IOTest		IM1646
IgG1 (mouse)

The CD13 antigen is a transmembrane glycoprotein with a large extracellular region and a small intracellular NH2-terminal tail. It has a molecular weight of 150 kDa and is expressed on the cell surface as a homodimer. It is found on most cells of myeloid origin including neutrophils, eosinophils, basophils and monocytes from normal peripheral blood. It is absent from B and T cells as well as from red blood cells and platelets. This molecule is found on the surface of committed progenitor cells defined as the Granulocyte-Monocyte Colony Forming Units (CFU-GM) in normal bone marrow. There are up to five subpopulations of CD13 molecules possessing different levels of glycosylation, which may explain the different binding patterns of various CD13 antibodies. MY7 antibody was evaluated during the First International Workshop on Human Leukocyte Differentiation Antigens. SJ1D1 antibody was evaluated during the Third Workshop. Immu103.44 antibody was evaluated during the Fifth Workshop.

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