CD11a

LFA-1 INTEGRIN aL-CHAIN

Clone & Isotype	Conjugate	Size	Format	Line		Part Number
25.3	Purified	0.2 mg	Freeze-dried			IM0157
IgG1 (mouse)	FITC	100 tests	Liquid	IOTest		IM0860
	PE	100 tests	liquid	IOTest		IM1433

The CD11a antigen, Leukocyte Function Associated molecule-1 (LFA-1), is the 180 kDa integrin aL-chain, non-covalently associated with the 95 kDa CD18 antigen (integrin b2). It promotes homotypic adhesion between lymphoid cells and heterotypic adhesion of lymphoid cells to the vascular endothelium. LFA-1 can interact with different ligands; the InterCellular Adhesion Molecules (ICAM): ICAM-1 (CD54), ICAM-2 (CD102) and ICAM-3 (CD50). CD11a antibodies react strongly with all leukocytes but do not recognize platelets. They react with peripheral blood T and B cells and with a portion of monocytes and granulocytes. They also stain thymocytes presents in bone marrow. 25.3 is a blocking antibody. It was evaluated during the Third International Workshop on Human Leukocyte Differentiation Antigens.

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