CD56
NK CELLS (N-CAM)
CD56 (NKH-1) antigen is a 140 kDa isoform of the neural cell adhesion molecule (N-CAM). Post-translational modifications to the polypeptide include N- and O- glycosylation, acylation, sulphation and phosphorylation. The different N-CAM isoforms have molecular weights ranging from 135 to 220 kDa. The CD56 antigen is moderately expressed on a subpopulation of peripheral blood large granular lymphocytes and on all cells with natural killer (NK) activity. CD56 antibodies do not react with granulocytes, monocytes or B cells. The NKH-1 antibody was characterized during the Second International Workshop on Human Leukocyte Differentiation Antigens.
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